Van de Ven Double Ends Everton's Run at New Stadium
The Dutch defender emerged as the first defender to net twice in a Premier League match for Spurs since the Belgian defender in March 2013.
Key points
Micky Van de Ven heads home twice in first half
The home side's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr nets final goal in dying moments
This loss is the Merseyside club's initial at their new ground
The Tottenham defender found the net on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and delivered the Toffees their initial loss at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the conclusion of last season.
But Spurs captain the Dutchman struck on two occasions from corners in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had equalized the tally a short while after Van de Ven's opener, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of chances, while Vicario made a succession of excellent stops to guarantee Tottenham went five away games without defeat in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to check the goal on the screen and the official ruled that Jack Grealish and the attacker were in an illegal position and had interfered with the Spurs keeper.
This victory elevates the manager's team into third place in the Premier League, five points off north London rivals and leaders Arsenal.
Everton remain in 14th position and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven excels in duties at both ends of pitch
Following a uninspiring midweek display in the European competition against the French side, where they managed a mere attempts on target, the manager opted for the French striker in attack instead of ex-Everton forward Richarlison.
The new arrival was failed to influence the game before being replaced for the substitute after 60 minutes on the field, but it emerged he wasn't needed in the final outcome.
Defender the Dutchman converted into an attacking force to be feared.
Spurs' first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an unmarked Van de Ven to head home.
And Ven de Ven - filling in as skipper in the Argentine's unavailability - added his next goal in added time as he rose above Jordan Pickford to head home.
The Dutchman was just as outstanding in defence, combining well with his defensive colleague as the pair handled excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees lacking striker's instinct
Everton's recent stadium had been a fortress, but it appears the novelty may have faded somewhat and supporters headed to the exits after Sarr's third for Spurs.
The end in Everton's winning streak at home will not be a major concern for David Moyes, but their attacking woes will be.
Beto and the other striker - the Toffees' pair of recognised strikers - had netted just one league goal combined before Sunday's outing.
And they were failed to add to that miserable tally on a wet and gloomy evening on in Liverpool.
The striker's performance was epitomized when he opted to overhead kick a clear chance from near the goal, despite having room and opportunity to readjust for a simpler attempt that would have challenged the keeper.
The substitute, too, failed to make an impact after coming on for the starter in the 65th minute.
It wasn't for a shortage of chance. Most of the home side's attacks came through Grealish and Ndiaye, who relentlessly whipped threatening balls into the Tottenham box.
Upcoming fixtures for both teams?
Everton: Moyes' men travel to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on late October for their next round League Cup match against Newcastle.